Groups
Applied Computational Cancer Research
“Wolfgang und Gertrud Böttcher Stiftungsprofessur”
Stiftung Universitätsmedizin Essen
The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.
Contact
Girardethaus | Girardetstr. 8
House 8, 2nd floor
45131 Essen
Recent Publications
G. Lodde, J. Dollani, W. Galetzka, P. Mohr, F. Meier, R. Gutzmer, M. Weichenthal, J. Utikal, R. Herbst, U. Leiter, C. Pfohler, B. Schilling, P. Terheyden, C. Berking, A. Sucker, A. Stang, F. Rambow, D. Tilkorn, A. Roesch, A. Zaremba, L. Zimmer, A. Tasdogan, D. Schadendorf, S. Ugurel, K. Griewank, and E. Livingstone.
Melanoma of unknown primary shows oncogenic pattern and clinical course of sun-exposed melanoma.
Br J Dermatol. 2026. [doi] [url]
M. Baures, A. S. Vieira Aleixo, E. Pacreau, A. Koshy, V. Friedrich, M. Diedisheim, M. Raigel, Y. Hua, C. Dariane, F. Boutillon, L. Kenner, J. C. Marine, G. Laverny, D. Metzger, F. Rambow, J. E. Guidotti, and V. Goffin.
Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy.
EMBO Mol Med. 2026. [doi] [url]
C. M. Thielmann, J. A. Seier, L. Schielke, L. J. Albrecht, L. Zimmer, E. Livingstone, A. Zaremba, G. Lodde, J. Dissemond, W. Sondermann, F. Krefting, A. Tasdogan, A. Roesch, E. Hadaschik, F. Rambow, K. Griewank, S. Ugurel, D. Schadendorf, and J. M. Placke.
Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients.
Front Immunol. 2025. [doi] [url]
K. Theunis, S. Vanuytven, I. Claes, J. Geurts, F. Rambow, D. Brown, M. Van Der Haegen, O. Marin-Bejar, A. Rogiers, N. Van Raemdonck, E. Leucci, J. Demeulemeester, A. Sifrim, J. C. Marine, and T. Voet.
Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones.
Nucleic Acids Res. 2025. [doi] [url]
Team
Head of Research Group
- Prof. Dr. Florian Rambow
- florian.rambow@uk-essen.de
Administration
- Andrea Tonk
- andrea.tonk@uk-essen.de
- +49 201 723 778 25
Lab Manager
- M.Sc. Samira Makhzami
- samira.rambow-makhzami@uk-essen.de
Researchers
- Dr. Peihua Zhao
- mail@mail.de
- Dr. Saniya Arfin
- mail@mail.de
- Dr. Stavroula (Evie) Petroulia
- mail@mail.de
- Dr. Carl Maximilian Thielmann
- Associated UMEA Clinician Scientist
- mail@mail.de
- Dr. Anne Zaremba
- Associated UMEA Clinician Scientist
- mail@mail.de
- Dr. Georg Lodde
- Associated UMEA Clinician Scientist
- mail@mail.de
Research Assistants
- M.Sc. Lea Otte, Ph.D. Candidate
- mail@mail.de
- M.Sc. Hua Dong, Ph.D. Candidate
- mail@mail.de
Tech
- B.Sc. Marcel Bargull
- mail@mail.de
Alumni
- Dr. Yichao Hua
- mail@mail.de
- Dr. Linqian Weng (Jenny)
- mail@mail.de
